Likewise, DAPK (death-associated protein kinase), MGMT (O-(6)-methyl guanine-DNA methyl transfer-ase), RASSF1 (Ras association domain-containing protein 1), and ADAM23 (ADAM dis-integrin and metalloproteinase domain 23) are among the most frequently methylated tumor suppressor genes in LSCC tissues, showing high diagnostic and prognostic potential [143,144]. The gene discussed is MGMT; the disease is neoplasm.