CD4 and cancer: In detail, it was demonstrated that both chemokine receptors were highly expressed in laryngeal cancer tissues, in LNM and in CD4 + CD25 + Foxp3+ T-regs, also showing a direct involvement in driving cancer cell migration and immune tolerance by recruiting CD4 + CD25 + Foxp3+ T-regs to cancer sites and stimulating LSCC onset, invasion, and metastasis.