Our observation may well explain a previous report on HCC that the presence of a high level of MYC protein was associated with high sensitivity to CDK7 inhibition, and that exogenous MYC expression in cancer cells with a low level of endogenous MYC led to a greater sensitivity to THZ1 as compared to that of vector control–transfected cells [30]. The gene discussed is MYC; the disease is hepatocellular carcinoma.