Other studies demonstrated that CD278/CD275 ligation may promote Th2 [332,333], Th17 [315] and Tfh [311] polarization, and may promote overall T cell activation [317,334,335], but may also yield activation of innate immune cell types, including DCs [336,337], natural killer T (NKT) cells [313] and ILCs [314], and inhibit tumor cell migration [338]. This evidence concerns the gene ICOSLG and neoplasm.