IL10 and neoplasm: Binding to its cognate ligand CD275 (ICOSL, ICOS ligand), another B 7 family member [316], which is apparent on DCs [317,318,319], B cells [320], several non-immune cells [321,322,323,324] and tumor cells [325], caused Treg expansion [323,326,327,328], IL-10 release by activated T cells [318] and attenuated B-cell activation [329,330,331].