EGF and neoplasm: Further, cancer-associated fibroblasts (CAF) as activated by factors produced by tumor and stromal cells (e.g., TGF-β, EGF, platelet-derived growth factor and fibroblast growth factor 2) [32], support tumor growth by secreting EGF, hepatocyte growth factor, insulin growth factor-like family member (IGFL)1 and IGFL2 [33], and promote angiogenesis via VEGF release [34].