PTEN and fatty liver disease: To further explore TIA1′s function in vivo in hepatic tumorigenesis occurring in a context of steatosis/fibrosis, TIA1 was knocked down using AAV8 vectors in hepatocytes-specific PTEN knockout (LPTENKO) mice, a mouse model sequentially developing hepatic steatosis, inflammation, fibrosis and hepatic tumors around 11–12 months of age [20,33].