Finally, analysis of polysomal RNAs from livers of CTL and TIA1 knockdown LPTENKO mice (Figure 4G) indicated that consistent with a lack of effect of TIA1 downregulation on tumor growth and progression, markers for proliferation (Mki67, Pcna, Cdkn1a, Cdkn1b, Cdc25a) and inflammation (Il1b, Tgfb) were unchanged. This evidence concerns the gene TIA1 and neoplasm.