PCNA and neoplasm: Finally, analysis of polysomal RNAs from livers of CTL and TIA1 knockdown LPTENKO mice (Figure 4G) indicated that consistent with a lack of effect of TIA1 downregulation on tumor growth and progression, markers for proliferation (Mki67, Pcna, Cdkn1a, Cdkn1b, Cdc25a) and inflammation (Il1b, Tgfb) were unchanged.