Finally, steroids are a cornerstone of MM therapy, and circPVT1 was increased in glucocorticoid-resistant cells, while its reduction increased sensitivity to glucocorticoid administration, stimulated programmed cell death, and blocked cell growth in resistant cell lines and xenograft models via an increase in caspase-3 and PARP and a decrease in BCL2 [63]. Here, CASP3 is linked to Miyoshi myopathy.