EGFR and neoplasm: The HPV/p16 status, tumor-infiltrating lymphocytes (TILs) rate, Epidermal Growth Factor Receptor (EGFR) overexpression, circulating HPV-DNA and blood biomarkers [Neutrophil-to-lymphocyte ratio (NLR), Systemic Index of Inflammation (SII), absolute number of leukocytes and neutrophils, hemoglobin level] were the most frequently studied biomarkers [29,30,31,32,33,34,35,36].