On a separate note, drugs targeting distinct molecular structures such as the BCL-2 inhibitor venetoclax (VEN) [9], the anti-CD33-antibody gemtuzumab ozogamicin (GO) [10,11] and glasdegib, a selective inhibitor of hedgehog signaling [12], have dramatically improved the treatment portfolio for AML patients. This evidence concerns the gene BCL2 and acute myeloid leukemia.