Several cytokines are secreted and released by basophils: IL-4 (reduced the M2 macrophage polarisation in colon cancer-bearing mice leading to further survival) [189], IL-13 (contributed to activate innate immune responses in melanoma and fibrosarcoma-bearing mice resulting in inhibiting of tumour growth [190], CCL3 [157] and CCL4 [191] (both involved in CD8+ T cell infiltration in murine colon cancer) [157] (Table 1). The gene discussed is CD8A; the disease is melanoma.