It is worth noting that among the most recent studies, the IFN-alpha/beta Receptor 1 (IFNAR1) degradation [118], a notion that was supported by a previous study [119], through the correlation between Type I interferon (IFN-I) downregulation and granulocytic myeloid-derived suppressor cells (G-MDSCs) immunosuppression, has been considered a new mechanism for tumour evasion. This evidence concerns the gene IFNAR1 and neoplasm.