Factors implicated in promoting their role as anti-tumour cells in the TME, leading to limit tumour growth, include hypoxia-induced C-X-C chemokine ligand 1 (CXCL1), CXCL2 and CXCL5 expression [144]; proto-oncogene c-met (MET) [145]; hydrogen peroxide (recruit leukocytes to transformed cells like in wounds) [146]; chemokines and cytokines signals (many of them are also important in acute wounding). The gene discussed is CXCL1; the disease is neoplasm.