Tumour cell-derived soluble molecules implicated in promoting macrophage pro-tumourigenic phenotype (TAM M2 polarisation) are sonic hedgehog (SHH), involved in suppressing the recruitment of CD8+ T cell, expression of osteopotin (OPN) in tumour cells and mucin 1 (MUC1) involved in inducing M2 phenotype [233]. Here, SHH is linked to neoplasm.