Whereas IL-10 inhibit LCs migration [98], IL-1β contribute to their proliferation and their pro-tumourigenic cytokine network is stimulated [167] leading to tumour pathogenesis [98] through the dysregulation of signalling pathways in human dysplastic oral keratinocytes (DOK), as demonstrated in OSCC cells [167] (Table 1). The gene discussed is IL10; the disease is neoplasm.