M2 macrophages, may stimulate tumour growth in vivo [253], since, they are involved in promoting metatastasis by expression of MMPs, serine proteases, cathepsins, and decompose various collagens, and other components of ECM and angiogenesis by coordinated expression of VEGF, basic fibroblast growth factor (BFGF), IL-1,IL-8, TNF-α, MMP2, MMP9 and NO [233]. Here, TNF is linked to neoplasm.