Nevertheless, is well-known that MCs through releasing IL-1, IL-4, IL-6, IL-8, TNF-α, IFN-γ, TGF-β, MCP-3, MCP-4, leukotriene B4 (LTB4) and chymase can contribute to inflammation, inhibition of tumour cell growth, and induction of tumour cell apoptosis [223]. This evidence concerns the gene IFNG and neoplasm.