IFNG and neoplasm: It is worth noting that molecules such as CD96, CD161, and CD244 expressed by NK cells can act as co-receptors and regulate cytolytic activity and cytokine production, being IFN-γ as one of the most frequent cytokines that are secreted by NK as result of activating receptor NKG2D (Natural Killer Group 2D) on their surface, that play a pivotal role in anti-tumour activity, due to its anti-proliferative, anti-angiogenic, and pro-apoptotic effect [330].