Furthermore, it should be pointed out that the expression of Protein kinase N2 (PNK2) is involved in regulating TAMS since it is able to promote M1 macrophage and suppress tumour-associated M2 macrophage polarisation and tumour growth via regulating Dual-specificity phosphatase 6-extracellular signal-regulated protein kinases 1 and 2 (DUSP6-Erk1/2) pathway in human colon cancer tissues, thereby being related to good prognosis [249]. Here, MAPK3 is linked to neoplasm.