CD8A and neoplasm: Th1 cells, characterised by the production of IFN-γ, IL-2 and TNF-α, are notable for its capacity to activate macrophages, neutrophils, NK cells and CD8+ T cells and are considered, along with the CD8+ T cells, the main players against tumours [431], due to their cytotoxic and phagocytic activity, among others [216].