Although our understanding of the roles played by chemerin in the context of PCa are fairly limited, it was shown that human tumors exposed to exogenous chemerin upregulate PTEN expression with the concomitant suppression of PD-L1 expression, possibly by the activation of the PI3K/Akt/mTOR signaling pathway, a phenotype that was abrogated following CMKLR1 knockdown [438]. Here, PTEN is linked to posterior cortical atrophy.