Moreover, it was shown that in comparison to CXCR4, CXCR7 more prominently contributes to PCa cell migration as CXCR7-depleted PC-3 cells grow significantly slower in vitro and much slower in vivo, indicating CXCR7 may indeed control PCa cell proliferation in vivo [533]. The gene discussed is ACKR3; the disease is posterior cortical atrophy.