CXCR4 and posterior cortical atrophy: Fittingly, CXCL12 methylation downregulates tumor intrinsic CXCL12 protein expression, disrupting cellular feedback mechanisms to internalize membranous CXCR4 in PCa, thereby fostering metastasis [514], which is suggestive of the possible therapeutic potential of CXCL12 inhibitors [515].