In that context, several inhibitors of the CXCR4/CXCL12 axis and different effectors upstream and downstream the CXCR4/CXCL12 signaling pathway resulted in an inhibition of PCa growth, chemo-sensitization and suppression of EMT, migration and bone metastasis [516,517,518,519,520,521,522]. The gene discussed is CXCR4; the disease is posterior cortical atrophy.