Alternatively, the enhanced expression of cytosolic superoxide dismutase (SOD1) that interacts directly with the first intracellular loop (ICL1) of CXCR4 and regulates CXCL12/CXCR4-mediated AKT activation leads to apoptosis and cell migration in PCa cells under hypoxic conditions when SOD1 is present [524]. The gene discussed is AKT1; the disease is posterior cortical atrophy.