In addition to being substrates for enhanced PCa lipogenesis, these FFAs are taken up by proximal cancer cells and are utilized as a pivotal energy source driving cancer progression and metastasis, blocking either the fatty acid transporter CD36, or the membrane-bound transcription factor, sterol-regulatory element binding protein (SREBP) and halts disease progression and metastasis in different preclinical models of PCa [136,137,138]. This evidence concerns the gene CNBP and posterior cortical atrophy.