SMAD4 and B-cell chronic lymphocytic leukemia: Considering the relevance of SMAD-4 as a binding partner common to all RSmads, indispensable for shuttling SMAD-4-RSmads complexes to the nucleus and to activate or repress hundreds of target genes at once, we decided to evaluate the expression levels and cellular localization of SMAD-4 in our CLL cohort.