SMAD4 and B-cell chronic lymphocytic leukemia: Representative images of leukemic cells expressing SMAD-4 at the different compartments in each different CLL subgroup and an extended microscopy analysis of SMAD-4 localization in seven stable and eight progressive U-CLLs from the validation cohort are shown in Figure 3C (p = 0.040, Mann–Whitney Unpaired test, n = 15).