Interestingly, in progressive U-CLL, we also found a significant down-regulation of p21−Cip1 and KLF10 mRNA expression compared with the stable cases (p = 0.006, n = 25 and p = 0.032, n = 26, respectively, Mann–Whitney Unpaired test), Figure 2. This evidence concerns the gene CDKN1A and B-cell chronic lymphocytic leukemia.