BIRC3 and colorectal carcinoma: The location of both cIAP-1 and cIAP-2 was assessed by Ponnelle et al. [71] who found that, although the proteins were present in both nucleus and cytoplasm, cIAP-1 was most frequently expressed in the nucleus (85%) and cIAP-2 in the cytoplasm (82%) in CRC samples [71].