The other six genes, peroxisome proliferator-activated receptor delta (PPARD), B-cell lymphoma 3 (BCL3), cluster of differentiation 44 (CD44), protein fosB (FOSB), myelocytomatosis (MYC), and signal transducer and activator of transcription 1 (STAT1), were detected with high frequency among severe asthmatics and lung cancer patients (Supplementary Table S4) in the leading-edge analysis. The gene discussed is FOSB; the disease is lung cancer.