To validate the findings of the microarray analysis, the six genes identified (PPARD, BCL3, CD44, FOSB, MYC, and STAT1), along with POSTN and LUM, were assessed using RT-qPCR in 11 archival tissue biopsies from four severe asthmatics (AS), three asthmatics who developed lung cancer (AC), and four lung cancer (LC) patients. This evidence concerns the gene BCL3 and laryngotracheoesophageal cleft.