EGFR and pulmonary emphysema: As mentioned above, the best-characterised genetic mutation in NSCLC was EGFR (both exon 19 and exon 21 mutations) linked to contrast [28], Laws-Energy [29], median Hounsfield unit (HU) [30], SUVmax [54], pleural retraction [14], small size [14,23], speculation [23], irregular nodules [18], poorly defined margins [18], ground glass [18,31], emphysema [32], locoregional infiltration [32], and “normalised inverse difference moment” [26], as well as combined radiomic profiles [24,25,33,55,56].