By far, the best-characterised genetic mutation in NSCLC is EGFR (both exon 19 and exon 21 mutations) linked to contrast, Laws-Energy, median Hounsfield unit (HU), SUVmax, pleural retraction, small size, speculation, irregular nodules, poorly defined margins, ground glass, emphysema, locoregional infiltration, and “normalised inverse difference moment”, as well as combined radiomic profiles [26,27,28,29,30,31,32,33]. The gene discussed is EGFR; the disease is pulmonary emphysema.