We then conducted IHC staining in ccRCC patients’ samples (Figure 1l) and found that the patients with higher ERβ staining (+/++) were more likely to be VE-cadherin (+) (Figure 1m, p < 0.01) and VM (+) (Figure 1n) than the patients with lower ERβ (−/±) staining. This evidence concerns the gene ESR2 and nonpapillary renal cell carcinoma.