BRCA1 and neoplasm: Among the 760 tumor samples successfully sequenced, 178 (23.4%) cases harbored a pathogenic/likely pathogenic (P/LP) mutation, 74 (9.7%) cases showed a variant of uncertain significance (VUS) only, and 508 (66.8%) were defined as BRCA1 and BRCA2 wild type (wt) (Figure 1).