ER stress-induced autophagy is closely related to the PERK-eIF2α cell signal transduction pathway, which was shown in murine experiments: the gene knockout of PERK-inhibited cell autophagy was induced by the PERK-eIF2α pathway and strikingly decreased the number of autophagosomes in the cytoplasm in mouse embryonic tumor cells [47]. The gene discussed is EIF2AK3; the disease is neoplasm.