Kinsey et al. demonstrated that a combination of the MEK-inhibitor trametinib and the autophagy inhibitors chloroquine (CQ) and hydroxychloroquine (HCQ) promotes a regression of RAS-RAF-MEK-ERK-driven pancreatic ductal adenocarcinoma cells [130]. The gene discussed is MAP2K7; the disease is pancreatic ductal adenocarcinoma.