IDH1 and glioblastoma: As expected, an analysis of the distribution of nonsynonymous mutations showed that the TMB-high group had a higher incidence of mutations typical for glioblastoma (PTEN: 29% vs. 5%; EGFR: 17% vs. 5%), while the opposite was true for mutations associated with low-grade gliomas (IDH1: 77% vs. 7%).