Remarkably, KRT7-high expression was significantly associated with an increased risk of developing bone metastasis (28 events, log-rank = 4.07, p = 0.044) (Figure 5B) and an increased risk of PC-associated death at 15 years (15 events, log-rank = 3.98, p = 0.046) (Figure 5C). Here, KRT7 is linked to pachyonychia congenita.