HSPA8 and cancer: CMA has been implicated in the growth of cancer [196], and it has been demonstrated that silencing LAMP2A reduces cancer cell proliferation and decreases transcription of heat shock cognate protein 70 (HSC70); moreover, knocking out of LAMP2A exacerbates the accumulation of pathological proteins associated with neurodegenerative diseases such as -synuclein, mutant huntingtin (mHTT), and Tau [196].