Kanai et al. [132] similarly analyzed the ratios of LCA-reactive Tg to total Tg from the sera of healthy individuals and patients with thyroid cancers utilizing an enzyme-linked immunofluorescence assay (ELISA) for the detection of Tg, which has a much higher sensitivity for the detection of Tg at low serum concentrations. The gene discussed is TG; the disease is thyroid cancer.