Based on previous observations that the histone deacetylase SIRT7 is upregulated in thyroid cancer [89,90], and given the established role of Akt in thyroid tumorigenesis [79,80,91], Li et al. [5] recently investigated whether SIRT7 stimulates thyroid cancer proliferation and invasiveness by activating Akt. Here, SIRT7 is linked to thyroid gland carcinoma.