It should be noted that although the elegant in vitro experiments performed by Shaik et al. [31] support the concept that ubiquitin-dependent degradation of VEGFR2 decreases the aggressiveness of thyroid cancer by suppressing angiogenesis and the migration of the cancer cells, it will be important in future studies to determine whether the same molecular and cellular mechanisms are involved in patients with thyroid cancer. This evidence concerns the gene KDR and cancer.