Importantly, when in the same report [21] studies were performed on tumor and normal adjacent thyroid tissue from patients undergoing thyroidectomy for cancer, some patients had particularly high levels of UBE4A combined with reduced PCBP1 levels in the cancer; these patients had a less favorable clinical outcome than the patients with less pronounced changes in UBE4A and PCBP1 levels. The gene discussed is UBE4A; the disease is neoplasm.