However, there was more overlap between the significantly upregulated genes (p.adjust ≤ 0.05 and fold-change ≥ 1.5) between the migratory cells from our model and the lymph node-derived CLL gene expression signature identified by Herishanu et al. than the CD40L co-cultured CLL cells (46% vs. 25% respectively) (Figure 1E) [5]. The gene discussed is CD40LG; the disease is B-cell chronic lymphocytic leukemia.