NFKB1 and B-cell chronic lymphocytic leukemia: The differential expression data were input into a Cytoscape representation of known CD40L downstream pathways, which revealed a consistent upregulation of many of the relevant RNAs, e.g., (CD40, TRAFs) and subsequent activation of NF-κB (Figure S3), emphasizing the importance of the microenvironment on CLL survival and proliferation.