Next, we analyzed the RNA-seq differential expression data relating to the FAK signaling pathway, presented as a Cytoscape network (Figure 2A), which indicated that downstream signaling pathways regulating cytoskeletal reorganization, cell motility, and GTPase regulation were upregulated in the migratory CLL cells, whereas the MEK-ERK pathway, which modulates cell proliferation, was not differentially expressed. Here, PTK2 is linked to B-cell chronic lymphocytic leukemia.