INS and Hyperglycemia: Regardless of baseline hyperglycemia status, mean FPG levels generally normalized over time, which was most likely attributable to antidiabetic medications (e.g., metformin and/or insulin), which were used to manage blood glucose levels in 163 of 187 patients (87%) with hyperglycemia, and early discontinuation of alpelisib due to hyperglycemia, which occurred in 18 of 284 patients (6%) in the alpelisib treatment group [9,17].