Other genes related to T2DM are insulin receptor substrate 1 gene (IRS1) and IRS-2, ABCC8, Phosphatase and Tensin Homolog (PTEN), Zinc Transporter-8 Gene (SLC30A8), GATA Binding Protein 6 (GATA6), ISL LIM Homeobox 1 (ISL-1), Transcription Factor 7-like 2 (TCF7L2), Insulin-like Growth Factor 2 mRNA-Binding Protein 2 (IGF2BP2), among many others [48,50,56]. This evidence concerns the gene ISL1 and type 2 diabetes mellitus.