LPA and cardiovascular disorder: In fact, a meta-analysis of 27 studies, published in 2018, aimed at assessing the association between cardiovascular disease and several classical risk factors, adding up to 41,831 subjects and 6629 cardiovascular events, found that DM was indeed an independent risk factor in HeFH (OR 1.95; 95% CI: 1.33–2.57), along with age, male sex, hypertension, body mass index, smoking, increased Lp(a), low HDL-c and a family history of cardiovascular disease [14].