A large meta-analysis of genetic association studies assessing the effects of cholesterol-lowering variants in or near NPC1L1, HMGCR, PCSK9, ABCG5/G8 and LDLR showed an overall increased risk of DM with an odds ratio of 1.19–2.42 for every 1 mmol/L (38.6 mg/dL) reduction in LDLc [110]. Here, PCSK9 is linked to diabetes mellitus.