To find articles matching the topic of the manuscript, PubMed and WorldWideScience databases were searched for keywords “obesity”, “adipokines”, “chronic kidney disease”, “leptin”, “adiponectin”, “zinc-α2-glycoprotein”, “adipose triglyceride lipase”, “cardiovascular risk”, and their various combinations. Here, ADIPOQ is linked to obesity due to melanocortin 4 receptor deficiency.