Likewise, RBP1, which is responsible for the transport of intracellular retinol, exhibited the classic cytoplasmic expression in hepatic stellate cells and myofibroblasts in healthy human liver, whereas in human HCC RBP1 staining was aberrantly distributed in the cytoplasm and nucleus of neoplastic hepatocytes as well as in a few myofibroblasts in non-tumor liver tissue while RBP1 expression was almost absent in hepatic stellate cells [210]. This evidence concerns the gene RBP1 and neoplasm.