In animal models, oleuropein prevented myocardial remodeling in heart failure—by inhibiting the angiotensin-converting enzyme [145], in doxorubicin cardiomyopathy—by modulating nitric oxide synthases and other mechanisms [146], and in autoimmune myocarditis [147] and sepsis-induced myocardial injury—by NF-κB inhibition [148]. Here, ACE is linked to heart failure.