Regarding mechanisms of action, oleuropein was able to decrease cell number and motility in the human melanoma cell line A375—decreasing their glycolytic capacity (Warburg effect)—at the expense of glucose transporter 1 (GLUT-1), pyruvate kinase M2 (PKM2), and monocarboxylate transporter 4 (MCT4) inhibition [334]. This evidence concerns the gene PKM and melanoma.