With respect to Alzheimer’s disease, oleocanthal was shown to increase neuronal clearance of β-amyloid by increasing P-glycoprotein (P-gp) and LDL receptor-related protein-1 (LRP1) levels in mouse brains [339], while restoring the blood–brain barrier function and reducing neuroinflammation through inhibition of PYD domain-containing protein 3 (NLRP3) inflammasome and inducing autophagy through activation of the AMP-activated protein kinase/Unc-51-like autophagy activating kinase 1 (AMPK/ULK1) pathway [340]. This evidence concerns the gene LRP1 and Alzheimer disease.