IGFBP3 mediates the induction of p21CIP1/WAF1 by 1,25-(OH)2D3 in prostate carcinoma cells [136], and microRNA miR-145 the repression of CDK2, CDK6, CCNA2, and E2F3 genes and the antiproliferative effect of 1,25-(OH)2D3 in gastric cancer cells [137]. The gene discussed is CDKN1A; the disease is prostate carcinoma.