NAT2 and gastric cancer: In some systems (colon and gastric cancer cells), 1,25-(OH)2D3 downregulates other proliferative genes such as FOS, JUN, JUNB, and JUND proto-oncogenes, G0S2 (G0/G1 switch 2), and CD44, while it upregulates GADD45A (growth arrest and DNA damage 45a), MEG3 (Maternally expressed gene 3, a lncRNA) and NAT2 (N-acetyltransferase 2) [131,132,133,134].