A recent study on peanut allergy in children indicated that OIT with the peanut allergen was associated with a reduction in peanut-specific IL-4, IL-5, IL-10, and IL-2 production by PBMCs compared to the placebo group, as well as a significant increase in peanut-specific IgG4 levels, with excellent safety profile [21]. The gene discussed is IL4; the disease is peanut allergic reaction.