According to the current VCOG-CTCAE grading system [23], the adverse effects of COP chemotherapy (Supplementary Table S2) are hematologic toxicity (anemia, leukopenia, neutropenia, azotemia and elevated alanine aminotransferase (ALT)) and signs of anorexia, vomit, or diarrhea, as indicated in Table 3. The gene discussed is GPT; the disease is Decreased total neutrophil count.