According to the current VCOG-CTCAE grading system [23], the adverse effects of COP chemotherapy (Supplementary Table S2) are hematologic toxicity (anemia, leukopenia, neutropenia, azotemia and elevated alanine aminotransferase (ALT)) and signs of anorexia, vomit, or diarrhea, as indicated in Table 3. This evidence concerns the gene GPT and neutropenia.