IL1B and toxemia of pregnancy: Although the exact pathogenic mechanism of pregnancy toxemia is not known, Yarim et al. [179] propose a key role for cytokines and chemokines, including interleukin-1β (IL-1β), tumor necrosis factor alpha (TNF-α), and monocyte chemotactic protein-1 (MCP-1), proving an increase, related to the severity of the disease, so they could be used to monitor the prognosis of pregnancy toxemia in sheep [179].