CD40LG and infection: After excluding the 63 participants who tested IgM-positive for DENV (i.e., 32 participants with evidence of ZIKV and 31 with evidence of CHIKV), clinical presentations were compared in 213 participants with ZIKV mono-infections, 55 with CHIKV mono-infections, and 58 with sequential ZIKV/CHIKV infections.