Hepatocyte Growth Factor (HGF) ligand binding triggers receptor dimerization and autophosphorylation of tyrosine residues Y1234/5 in the activation loop of the kinase domain, and Y1349 in the C-terminal tail, a docking site for downstream effectors that facilitate breast cancer cell survival, proliferation, invasion and scattering [35]. This evidence concerns the gene HGF and breast carcinoma.