Accordingly, B[a]P (1 μM,AhR positive control), AOH (10 μM), ATX-II (1 μM), andbinary combination incubations (1 h) enhanced nuclear/cytosolic ratiosof Nrf2 (Figure 5).These results are in line with previous studies describing the capacityof AOH (10 μM) and ATX-II (5 μM) to induce oxidative stressvia the Nrf2-ARE pathway in HT29 cancer cells30,57 and HCEC-1CT cells.29 Furthermore, AOH(10 μM) was recently reported to induce generation of ROS andmodulate SOD1 gene expression and the protein level in human prostatecells. The gene discussed is SOD1; the disease is cancer.