APOE and memory: In the placebo arm, there was a dose-dependent relationship between APOE ε4 genotype and patient-reported memory decline (p = .003 for trend across genotypes; ε4/ε4 carriers vs. non-carriers: OR = 1.46, 95% CI [1.03, 2.08]) and total ECog score (p = .009 for trend across genotypes; OR = 1.33, 95% CI [.94, 1.89]), but not executive functioning subscore (p = .77 for trend across genotypes; OR = 1.15, 95% CI [.78, 1.69]).