For the remaining two large clusters, we found either negligible (Fig 2C, lower right panel) or high (Fig 2C, lower left panel) correlation with infection-induced TF activities (Spearman rho = 0.04 and 0.58, p = 0.484 and 3.14e-27, respectively), but we found high drug-induced activity of SREBF1/2 transcription factors in these clusters, opposite to the inhibition of these TFs by SARS-CoV-2 infection. Here, TF is linked to infection.