Two other clusters (Fig 2C, upper middle and upper right panels) showed lower, but still significant correlation with infection TF activity signature (Spearman’s rho = 0.14 and 0.18, p = 0.0122 and 0.00174, respectively), with prominent increase of STATs and decrease of E2F4 transcription factor activity. The gene discussed is E2F4; the disease is infection.