We now demonstrate that circulating pDCs are still reduced several years after treatment in AIH patients, although they have persistent activation of immune cells, raising the question if the pDC suppression can play a central role in the pathophysiology of the chronic downregulation of immunoregulatory mechanisms seen in AIH, as DCs regulate proliferation and cytokine responses of CD4 and CD8 T cells, via IFN-I production.25 Here, CD8A is linked to autoimmune hepatitis.