TLR7 and systemic lupus erythematosus: Finally, a previous study has shown that Systemic Lupus Erythematosus (SLE) and AIH can reach 14% of similarity in their pathogenesis,30 an overlap that has been described in pediatric patients.32 It is speculated that DNA and RNA release by apoptotic cells in patients with SLE are potent stimuli to pDCs, via TLR-7 and -9 activation and high IFN-I production.