Results indicated that melatonin administration was able to decrease positive apoptotic cells (Choi et al., 2015; Esrefoglu et al., 2017), Bax expression (Mortezaee et al., 2017, 2018), and cleaved caspase‐3/caspase‐3 ratio (Choi et al., 2015), and induce higher levels of the antiapoptotic protein Bcl‐2 (Mortezaee et al., 2017, 2018), using different animal models with CCl4‐derived liver fibrosis. This evidence concerns the gene BCL2 and Hepatic fibrosis.