MAP3K5 and Hepatic fibrosis: Recent research conducted in a murine model of liver fibrosis has demonstrated that antifibrotic effects of melatonin are associated with the inhibition of apoptosis signal‐regulating kinase 1 (ASK1) activation by promoting its degradation in the liver through the blockage of TNF receptor‐associated factors (TRAFs)‐ASK1 interaction in response to oxidative stress and proinflammatory stimuli (D. J. Li et al., 2019).