One of the studies conducted by our group found that melatonin administration restrained autophagy induction in liver fibrosis by decreasing the number of autophagosomes, the LC3‐II/I ratio, and the expression of lysosome‐associated membrane glycoprotein 2 (LAMP2), UV radiation resistance‐associated gene protein (UVRAG), phosphorylated mammalian target of rapamycin (p‐mTOR), Beclin‐1, autophagy protein 5 (Atg5), Atg12, Atg16L1, and by increasing the levels of sequestosome‐1 (SQSTM1/p62) (San‐Miguel et al., 2015). This evidence concerns the gene ATG5 and Hepatic fibrosis.