In both cases, liver fibrosis was manifested together with an increase in ROS production, that induced the expression of the inflammatory cytokines interleukin‐6 (IL‐6), IL‐1β, and tumor necrosis factor‐alpha (TNF‐α), and reduced catalase (CAT), glutathione peroxidase (GPx), glutathione S‐transferase (GST), superoxide dismutase (SOD), and reduced glutathione (GSH), core proteins of the antioxidant system that protects tissues against ROS generation (Czechowska et al., 2015; Lebda et al., 2018). The gene discussed is IL1B; the disease is Hepatic fibrosis.