A significant elevation of the biochemical hemoglobin was observed in the Bev-R group compared with both the Bev-NR and Ctrl groups (Fig. 2C; 19 ± 0.1 g/dL vs. 11.1 ± 1.5 g/dL and 13.1 ± 0.6 g/dL, respectively); however, no significant changes in erythropoietin were observed in these mice either in absolute terms (Ctrl = 0.47 ± 0.19; Bev-NR = 1.32 ± 0.47; Bev-R = 0.97 ± 0.50 mIU/mL) or relative to tumor volume (Ctrl = 0.38 ± 0.18; Bev-NR = 0.59 ± 0.27; Bev-R = 6.23 ± 5.91 mIU/mL * cm3TUM). Here, EPO is linked to neoplasm.