CCR2 and neoplasm: To further determine whether CCR2/5i enhanced the function of infiltrating CD8+ T cells, we used the hemispleen metastatic liver mouse model to examine tumor-specific activity of systemic CD8+ T cells (isolated from the spleen) and tumor-infiltrating CD8+ T cells (isolated from liver metastases) using IFN-γ ELISA analysis with irradiated autologous KPC cells as the target (Fig. S4 E).