In vitro and in vivo experiments using 5 were performed to understand the effect of VDR inhibitionon RXRα and Importin-4 and MYCN expression, the critical VDRdownstream signaling nodes, and to examine its effects on the growthof ovarian cancer, neuroblastoma, pancreatic cancer, and medulloblastomacells. This evidence concerns the gene RXRA and ovarian cancer.