In vitro and in vivo experiments using 5 were performed to understand the effect of VDR inhibitionon RXRα and Importin-4 and MYCN expression, the critical VDRdownstream signaling nodes, and to examine its effects on the growthof ovarian cancer, neuroblastoma, pancreatic cancer, and medulloblastomacells. The gene discussed is VDR; the disease is pancreatic neoplasm.