Prior to testing antineuroblastoma activities of 5 using the well-established TH-MYCN+/+ transgenic mice, which spontaneouslydevelop neuroblastoma and recapitulate human neuroblastoma diseaseclosely,26,46 we establish via immunohistochemistry thatceliac ganglia harvested from homozygous TH-MYCN+/+ mice exhibit positiveexpressions of VDR, MYCN, and TH antigens (Figure 7a–c). Here, MYCN is linked to neuroblastoma.