Based on the described role of VDR in MYCN’s expressionin neuroblastoma,19 we examine the effectsof 5 treatment on the growth of spontaneous neuroblastomausing a homozygous tyrosine hydroxylase (TH)-MYCN transgenic model26 and investigate its effects on the populationof hematopoietic cells as a measure of off-target effects. Here, VDR is linked to neuroblastoma.