This result was consistent with those obtained with the above C918 graft tumors and metastasized tumors that only comprised epithelioid cells (Figs. 1e, g), suggesting that the epithelioid C918 cells are terminally differentiated and highly malignant cells that lack the flexibility of OCM1 cells to be reprogramed into cancer stem-like cells to become more heterogeneous after spheroid and tumor formation both in vitro and in vivo. The gene discussed is OCM; the disease is cancer.