Qualitative data are presented as numbers, followed by percentage in parentheses; continuous data are presented as mean, followed by range in parentheses; bone involvement was categorised according to PROMISE criteria [25]; PSA = prostate-specific antigen, Hb = haemoglobin concentration, PLT = platelet count, WBC; white blood cell count, TV50 = whole-body tumour volume assessed by semi-automated analysis of PSMA PET/CT acquisitions utilising percentage thresholding (50% of maximal lesion SUV). The gene discussed is KLK3; the disease is neoplasm.