High expression of metadherin has been observed in numerous cancer types.[47] In ovarian cancer, it significantly correlates with enhanced peritoneal and lymph node metastases, chemoresistance, and also poor survival.[48, 49] Moreover, mice with genetic metadherin ablation are viable and fertile, suggesting that metadherin could be highly tumor specific.[50]. This evidence concerns the gene MTDH and ovarian carcinoma.