IL10 and Peripheral demyelination: demonstrated that IL‐10 genetic deletion in mice induced severer WM lesions and demyelination in a hepatitis virus‐induced demyelination model.[17a] Moreover, inhibition of IL‐10/IL‐10R has been shown to block angiogenesis and migration in human umbilical vein endothelial cells.[41] Consistent with the previous report, we also confirmed a direct regulatory function of miR‐15a/16‐1 on IL‐10RA in HEK 293 cells.