Hyperbilirubinemia and thrombocytopenia are known adverse reactions to anti‐PD‐1/PD‐L1 therapy, bleeding is a known AE to antiangiogenic therapy, and patients with cirrhosis and HCC usually have complications of liver insufficiency, thrombocytopenia, and upper gastrointestinal bleeding. This evidence concerns the gene CD274 and hepatocellular carcinoma.