To determine the effects of PM2.5 on pyroptosis after ischemic stroke, the expression of GSDMD and GSDMD‐N was detected in NC+OGD/R, NC+OGD/R+PM2.5, NLRP3‐KD1+OGD/R, and NLRP3‐KD1+OGD/R+PM2.5 groups. The gene discussed is GSDMD; the disease is ischemic stroke.