The online database (http://gepia.cancer‐pku.cn/index.html) reported that the expression of IMPDH1 is higher in tumors (n = 369) than in normal tissues (n = 160, Figure S1A) and the expression of IMPDH1 is associated with HCC aggressiveness (Figure S1B), which are consistent with our results. Here, IMPDH1 is linked to hepatocellular carcinoma.