ITGB4 and squamous cell lung carcinoma: Wu et al.11proposed that ITGB4 can be applied as the diagnostic biomarker for both LUAD and lung squamous cell carcinoma, ITGB8 can be used as the diagnostic biomarker for lung squamous cell carcinoma, and ITGB4 can also serve as an underlying prognostic biomarker for LUAD.