In both chemo- and radio-resistant orthotopic PDX models of GBM, the combination of 9-ING-41 and CCNU demonstrated significant regression of established intracranial tumors and histologically confirmed cures.34 A chemosensitive GBM model demonstrated durable and long responses in mice treated with lomustine + 9-ING-41, with complete tumor regression and increase in mouse weight and health. Here, CCNO is linked to glioblastoma.