GSK3B and cancer: NF-κB is a transcription factor which is constitutively active in tumor cells and promotes anti-apoptotic molecule expression; its activation is particularly important in chemo- and radio-resistant cancer cells.30 GSK-3β is a positive regulator of NF-κB and a pro-oncogene, therefore, inhibiting GSK-3β could overcome NF-kB-mediated chemo-resistance in human cancers.