The novel pathways and genes implicated by EWAS studies of gestational age could provide a strong empirical basis for the selection of genes in targeted analyses in association with neuroimaging.27 For example, one of the genes identified in our EWAS has been implicated in neurodevelopmental disorders; biallelic mutations in INTS1 have been associated with a rare neurodevelopmental syndrome characterized by intellectual disability.78–80. This evidence concerns the gene INTS1 and neurodevelopmental disorder.