The candidacy of this locus, encoding NNAT and BLCAP, as a region of interest whose expression may be modified by perinatal exposures is supported by previous EWAS of gestational age, maternal body mass index, maternal smoking and schizophrenia.22,29,62,67–70 In addition, BLCAP was found to have reduced methylation in placental samples from women who had preeclampsia.71 This evidence concerns the gene NNAT and preeclampsia.